SNP Shot: Genomic Insights

Carpal tunnel syndrome is a type of neuropathy where nerve dysfunction causes pain, numbness, or tingling sensations (paresthesia), primarily affecting the wrist and hand. It commonly arises between the ages of 40 and 60, though it can occur at any age. Often, both hands are affected, though the intensity of symptoms can differ. When only one hand is affected, it is typically the dominant hand used for writing.

The pain or paresthesia in carpal tunnel syndrome is generally felt in the wrist, palm, and the first four fingers. These symptoms often appear during sleep and are evident upon waking. Individuals commonly shake their hand to alleviate the pain and numbness, a motion known as the flick sign. As the condition progresses, these symptoms also manifest during the day. Activities requiring manual dexterity, such as turning doorknobs, buttoning clothes, or opening jars, may become difficult. Certain wrist movements, like flexing or extending it while driving, typing, or holding a phone, can trigger these symptoms.

With prolonged carpal tunnel syndrome, muscle and nerve atrophy can occur in the affected hand, along with a decreased ability to perceive sensations. This loss of sensation may be misinterpreted as an improvement in the condition.

Inheritance:

Carpal tunnel syndrome is generally considered a complex disorder and is not typically inherited directly. However, having a family member with the condition may increase one's likelihood of developing it. When carpal tunnel syndrome is a symptom of a broader genetic syndrome, its inheritance pattern follows that of the underlying syndrome.