SNP Shot: Genomic Insights

Hypokalemic periodic paralysis is a disorder characterized by recurring episodes of significant muscle weakness, typically starting in childhood or the teenage years. These episodes frequently manifest as a temporary paralysis or inability to move the muscles of the arms and legs. These attacks can induce severe weakness or complete paralysis lasting from a few hours to several days. The frequency of these episodes varies greatly, with some individuals experiencing them almost daily, while others have them weekly, monthly, or very infrequently. Triggers for these attacks can be unpredictable, but factors like rest after strenuous activity, viral infections, or the use of certain medications can sometimes initiate them. Consuming a large meal high in carbohydrates or engaging in intense exercise in the evening can also sometimes lead to an attack upon waking the next day. While muscle strength typically returns to normal between attacks, some individuals may develop ongoing muscle weakness later in life.

A hallmark of hypokalemic periodic paralysis is low blood potassium levels (hypokalemia) during periods of muscle weakness. Scientists are currently studying the connection between these reduced potassium levels and the muscle dysfunction observed in this condition.

Inheritance:

Hypokalemic periodic paralysis follows an autosomal dominant inheritance pattern. This means that only one copy of the mutated gene in each cell is enough to cause the disorder to develop.