SNP Shot: Genomic Insights

Lattice corneal dystrophy type I is an eye condition impacting the cornea, the transparent outer layer essential for clear vision. This disorder causes amyloid deposits, abnormal protein clumps, to accumulate and cloud the cornea, resulting in visual impairment. These deposits specifically form within the stromal layer of the cornea, arranging themselves as branching, thread-like structures that create a characteristic "lattice" pattern.

People with lattice corneal dystrophy type I commonly experience recurring corneal erosions. These erosions, caused by separation between corneal layers, are intensely painful and often accompanied by photophobia (sensitivity to light). Typically, lattice corneal dystrophy type I affects both eyes (bilateral). Symptoms usually emerge during childhood or adolescence, leading to vision problems by early adulthood.

Inheritance:

The inheritance pattern for this condition is autosomal dominant. This means that only one copy of the mutated gene in each cell is enough to cause the disorder. In the majority of cases, an individual with lattice corneal dystrophy type I has inherited the altered gene from one affected parent.