SNP Shot: Genomic Insights

Multiple system atrophy (MSA) is a brain disorder that gradually worsens, impacting movement, balance, and the autonomic nervous system. The autonomic nervous system regulates involuntary bodily functions like blood pressure. Common autonomic symptoms in MSA include a sudden drop in blood pressure when standing (orthostatic hypotension), urinary problems, and erectile dysfunction in men.

There are two main types of MSA, classified by the most prominent symptoms at diagnosis. MSA-P is characterized by parkinsonism, featuring slow movement (bradykinesia), muscle stiffness, tremors, and postural instability. MSA-C is defined by cerebellar ataxia, which causes coordination and balance issues. This type can also involve speech difficulties (dysarthria) and problems with eye movement control.

MSA typically develops in older adults, with symptoms usually appearing around age 55. The condition progresses over time, and individuals with MSA typically live for about 10 years after symptoms begin.

Inheritance:

In most cases, MSA is sporadic, meaning it occurs randomly in individuals without a family history of the disorder. While rare cases of familial MSA have been reported, a clear pattern of inheritance is usually not evident.